Here, you can get an overview of the already confirmed speakers for the 2026 conference. More information will be added gradually.
Keynote Speakers
Stephane Bancel
Cambridge, USA
Talk title:
mRNA 2.0: The Race to Learn Faster
Content of the talk
How AI and China will reshape the next decade of medicines. mRNA 1.0 proved that we could move rapidly from sequence to product. mRNA 2.0 will be won by the fastest trusted learning system. AI will transform what we design; China will reset how quickly and economically we test it; delivery, human biology and regulatory credibility will remain the constraints.
Feng Zhang
Cambridge, USA
Talk title:
Exploration of Biological Diversity
Content of the talk
Many powerful molecular biology tools have their origin in nature, and, often, microbial life. From restriction enzymes to CRISPR-Cas9, microbes utilize a diverse array of systems to get ahead evolutionarily. We are interested in exploring this natural diversity through bioinformatics, biochemical, and molecular work to better understand the fundamental ways in which living organisms sense and respond to their environment and ultimately to harness these systems to improve human health. Building on our demonstration that Cas9 can be repurposed for precision genome editing in mammalian cells, we began looking for novel CRISPR-Cas systems that may have other useful properties. This led to the discovery of several new CRISPR systems, including the CRISPR-Cas13 family that target RNA, rather than DNA. We developed a toolbox for RNA modulation based on Cas13, including methods for precision base editing. We are expanding our biodiscovery efforts to search for new microbial proteins that may be adapted for applications beyond genome and transcriptome modulation, capitalizing on the growing volume of microbial genomic sequences and building on our bioengineering expertise. We are particularly interested in identifying new therapeutic modalities and vehicles for delivering cellular and molecular cargo. We hope that this combination of tools and delivery modes will accelerate basic research into human disease and open up new therapeutic possibilities.
Karen Beets
Niel, Belgium
Talk title:
Autoantigen mRNA-LNP vaccination drives therapeutic efficacy in preclinical models for autoimmunity
Content of the talk
Can mRNA-LNPs be used to restore antigen-specific immune tolerance without compromising their ability to induce strong immune responses? We show that autoantigen-encoding mRNA-LNPs, delivered systemically or intramuscularly, attenuate disease in preclinical models of MS and T1D, and that co-delivery of immunoregulatory mRNAs can further enhance therapeutic efficacy.
David Berman
Cambridge, USA
Talk title:
Individualized neoantigen therapy
Kimberly Bockley
Baltimore, USA
Talk title:
Lipid nanoparticle mediated delivery of therapeutic mRNA for the treatment of obstetric conditions
Content of the talk
Therapies specifically targeted to the placenta are important due to the low tolerance of off-target effects in pregnant women. This talk will explore new targeting approaches for mRNA lipid nanoparticles to modulate protein expression in the placenta which can be applied for a myriad of conditions such as preterm birth, placental insufficiency, and preeclampsia.
Brian Brown
New York City, USA
Talk title:
Investigating the role of muscle, liver, and DCs in mRNA vaccine immunogenicity
Content of the talk
mRNA vaccines can be expressed by a diversity of transfected cell types but how cell-type-specific expression influences immunity is poorly understood. Using synthetic microRNA target sites (miRT) to control mRNA vaccine expression, we are answering this question, and learning that mRNA vaccine immunogenicity is influenced by its expression patter.
Natasha Chaudhary
Brisbane, Australia
Talk title:
The Bicycle Reaction: A Single-Pot, Cell-Free Platform for Streamlined mRNA Medicine Manufacture
Content of the talk
mRNA medicines are traditionally made in two slow, contamination-prone steps: producing a DNA template, then transcribing it into mRNA. This talk introduces the Bicycle reaction, a novel cell-free method that combines transcription and reverse transcription into a single, self-amplifying reaction, exponentially producing high-quality mRNA directly from raw starting materials.
John P. Cooke
Houston, USA
Talk title:
Establishing a Personalized Cancer Vaccine Platform in a Hospital Setting: From Development to Clinical Deployment
Content of the talk
Houston Methodist Hospital was the first academic entity to develop, synthesize, encapsulate, validate and administer a personalized mRNA cancer vaccine in 2025. Academic programs for personalized RNA cancer vaccines, and other personalized RNA therapeutics, are emerging throughout the country. A distributed manufacturing model for personalized RNA therapeutics will be made more feasible by ongoing advances in automation, and further facilitated by academic consortia, industry partnering, regulatory innovation and recent federal funding, most specifically the ARPA-H GIVE program (Genetic Medicines and Individualized Manufacturing for Everyone). These developments will increase the affordability, accessibility and innovation in personalized RNA Therapeutics.
Davide De Lucrezia
Talk title:
From Melody to Symphony: Tuning mRNA for Peak Performance
Content of the talk
In mRNA drug development, the gene of interest often takes center stage. But like a soloist, it cannot deliver the full performance alone. UTRs, cap structures, poly(A) tails, chemical modifications, and delivery systems can all shape how an mRNA therapy performs.
This talk explores the shift from optimizing individual elements to tuning the complete mRNA system.
Gilles Divita
Pacific Palisades, USA
Talk title:
In vivo mRNA CAR-T cell engineering using peptide based nanoparticles targeting CD3 or CD8
Content of the talk
- In vivo CAR T generation using lentiviral or lipid nanoparticle vectors makes CAR-T cell therapy immediately accessible to patients but still remains limited.
- PEP-NP is a new peptide based mRNA delivery platform that enable reprogramming of circulating human T cells in vivo. By targeting specifically CD3 or CD8 T cells, PEP-NP allow the generation of anti-CD19 CAR-T cells, without toxicity, even after repeated administration.
- PEP-NPs offer a novel, redosable, off‑the‑shelf strategy for CAR T therapy.
Wayne Doyle
San Diego, USA
Talk title:
Lab-in-the-Loop: Closing the Design-Build-Test Gap in mRNA Development
Content of the talk
How a lab-in-the-loop platform accelerates mRNA therapeutic development by closing the gap between computational design and wet-lab validation.
Patrik Engström
San Diego, USA
Talk title:
Choosing the Right Enzyme for RNA Manufacturing and Therapeutics
Content of the talk
Purpose-built RNA polymerases influence IVT yield, capping efficiency, and dsRNA levels to match different RNA workflows.
Emily Freund
Palo Alto, USA
Talk title:
A novel engineered T7 RNA polymerase produces therapeutic mRNA
Content of the talk
Five engineered T7 RNAP variants were designed to significantly reduce double-stranded RNA contaminants during mRNA synthesis. Compared to wild-type T7, these optimized variants generate mRNA that yields higher expression and triggers lower innate immune stimulation both in vitro and in vivo. These improvements are robustly observed across multiple cell types and sequences when using either unmodified or N1psU-modified nucleotides.
May Guo
Boston, USA
Talk title:
Innovation in Enzymes and Assays for mRNA Manufacturing
Content of the talk
3 bullet points outlining presentation details:
- Engineering T7 RNAP to improve IVT performance and address key mRNA manufacturing challenges
- Developing T7 RNAP mutants to reduce dsRNA impurity, lower cap analog usage, and improve RNA integrity for long mRNA sequences
- Building high-yield IVT systems and reliable dsRNA quantification methods to support mRNA process development and QC
Akash Gupta
Houston, USA
Talk title:
mRNA-LNP-Mediated Immunomodulation for Precision Cancer Vaccines and Immunotherapy
Michael Hogan
Philadelphia, USA
Talk title:
Investigating the role of IL-1 signaling in reactogenicity and immunogenicity of clinical mRNA-LNP vaccines in mice
Keiji Itaka
Osaka, Japan
Talk title:
mRNA Cocktail Therapy for Ischemic Heart Disease: A Novel Approach Using Polyplex Nanomicelle
Ruaidhrí Jackson
Boston, USA
Sabah Kasmi
Zwijnaarde, Belgium
Talk title:
Engineering Lipid Nanoparticles for Efficient In Vivo Genome Editing of Hematopoietic Stem Cells
Content of the talk
This talk will discuss the development of lipid nanoparticles for in vivo delivery of mRNA and gene editing payloads to hematopoietic stem cells. The focus will be on nanoparticle design and extrahepatic delivery.
Myeonghwan Kim
Seoul, South Korea
Talk title:
Tailon technology enables low-dose, durable protein expression for infrequent enzyme replacement therapy
Content of the talk
mRNA stability enables sustained protein expression, which is particularly important for enzyme replacement and CAR-T therapies. Through MPRA screening of viral genomic sequences, we identified RNA elements that enhance mRNA stability and translation by promoting TENT4-mediated poly(A) tail extension, which we termed “Tailons.” We are applying these elements to develop mRNA-based therapies for urea cycle disorders that enable lower doses and less frequent administration.
Ben Kleinstiver
Boston, USA
Talk title:
From bespoke to more universal genome editing treatments
Content of the talk
There has been exciting recent progress with genome editing technologies benefitting patients in the clinic. To further enable the application of these transformative technologies, we are taking simultaneous protein and nucleic acid engineering approaches to develop tools that can generate diverse edits from small (nucleotide) to large (kilobase-scale) sequence changes, which together will enable the development of new genomic medicines.
Bowen Li
Toronto, Canada
Xiang Liu
Michigan, USA
Talk title:
Programming Antigen Fate in mRNA Vaccines Potentiates Cancer Immunotherapy
Content of the talk
This talk introduces PROTRAX, an mRNA vaccine platform that programs tumor antigen processing to enhance antigen presentation and strengthen the breadth, function, and persistence of antitumor CD8⁺ T-cell responses. Findings from preclinical tumor models and human immune-cell studies highlight its potential to improve cancer vaccination and combination strategies with immune-checkpoint blockade.
Tyson Lobb
St. Louis, USA
Talk title:
Unraveling the Role of Type I Interferon Signaling During mRNA Vaccination
Content of the talk
Type I interferon signaling is a key regulator of immune responses to mRNA vaccination, yet its precise role remains unclear. Our work is focused to understand how interferon signaling influences vaccine-induced immunity to improve mRNA-LNP efficacy.
Duccio Medini
Pittsburgh, USA
Talk title:
A Universal AI Design Framework and Brokerage Platform for Democratised Manufacturing of mRNA Therapeutics
Content of the talk
Bespoke, scale-dependent manufacturing processes still limit access to mRNA as a platform.
We present i) an AI-driven framework that decouples sequence design from manufacturing,
and ii) a brokerage model that democratises access to high-quality, multi-scale, end-to-end mRNA manufacturing.
Michael Mitchell
Philadelphia, USA
Jorge Rodrigo Mora
Brisbane, USA
Talk title:
A novel hydrophilic nanoparticle mRNA-based platform to induce immune tolerance in autoimmune diseases
Content of the talk
– Introduction to the NanoGalaxy hydrophilic nanoparticle (HNP) mRNA delivery platform
– HNP-mRNA biodistribution, immune cell engagement, and safety in mice and non-human primates
– Application of the HNP-mRNA platform to induce immune tolerance in autoimmune indications
Yunsun Nam
Dallas, USA
Talk title:
Substrate selectivity of the human RNA m5C methyltransferase NSUN2
Content of the talk
I will discuss the RNA features important for methylation by the m5C writer enzyme, NSUN2.
Kevin Ou
Vancouver, Canada
Lívia Palmerston Mendes
Vancouver, Canada
Talk title:
Challenging the PEG Paradigm: Stable Unshielded Lipid Nanoparticles Enable Potent Extrahepatic Delivery
Content of the talk
This presentation will discuss how lipid nanoparticles can be formulated without PEG-lipid or other surface-stabilizing excipients, challenging the need for steric shielding while opening new opportunities for systemic mRNA delivery beyond the liver. The data show that unshielded LNPs can maintain robust physicochemical stability while enabling extrahepatic mRNA delivery, with a focus on immune-cell targeting, favorable tolerability, and translational studies demonstrating that the formulations were well tolerated in non-human primates (NHPs).
Anna Marie Pyle
Connecticut, USA
Shu-Bing Qian
Ithaca, USA
Talk title:
Programmable mRNA translation initiation by trans-RNA
Content of the talk
We design capped antisense RNA oligos to guide ribosomes to specific start codons on target mRNA, thereby modulating translation initiation efficiency.
Liang Qu
Shanghai, China
Talk title:
Nucleoside-modified CircRNA and Chemically-synthesized RNA Vaccine
Content of the talk
Circular RNA (circRNA) exhibits extended stability and enhanced protein expression, and its translational efficiency and immunogenicity can be improved through nucleoside modification and rolling circle translation (RCT). However, it remains challenging to produce protein-encoding circRNA with modified nucleosides. Here, we identified a cap-independent translation enhancer (CITE) element from black beetle virus, termed BBV, which could drive the translation of nucleoside-modified RNA and RCT of engineered circRNA. Therefore, we established a nucleoside-modified circRNA platform that facilitated efficient translation with minimal immunogenicity, expanding the application scenarios of circRNA beyond vaccines.
Besides, personalized mRNA cancer vaccines hold great therapeutic promise, yet their production depends on multi-step in vitro transcription (IVT) that generates immunogenic dsRNA impurities and prolongs manufacturing to nearly three months, often missing the optimal therapeutic window. Here, we introduced a cap-independent translation enhancer BBV and developed protein-encoding RNA oligonucleotides (PEOs), which were chemically synthesized RNAs bearing 5ʹ-OH and 3ʹ-P termini that drive rolling circle translation after endogenous circularization. In melanoma and orthotopic glioma models, PEO vaccines significantly inhibited tumor growth and synergized with anti-PD-1 therapy. This proof-of-concept study built an IVT-free platform for rapid, safe, and highly druggable personalized cancer vaccines.
Manan Rajith Singh
Cambridge, USA
Talk title:
AI-Guided Discovery of Biodegradable Lipid Nanoparticles for Liver mRNA Delivery and Pulmonary Genome Editing
Content of the talk
In this presentation, I will discuss the development of biodegradable ionizable lipid nanoparticles for efficient mRNA delivery to the liver and lung. I will highlight our integration of combinatorial lipid discovery with peptide-barcoded high-throughput in vivo screening and AI-guided molecular design to identify next-generation delivery materials. I will also discuss their applications in pulmonary genome editing and other nucleic acid therapeutic strategies.
Hagen Richter
Munich, Germany
Talk title:
Closing the gap, R&D meets GMP
Content of the talk
Closing the gap between research and GMP manufacturing is a critical challenge in mRNA development. This presentation highlights how WACKER’s CRS activities, spanning template DNA, mRNA process development, and analytical characterization, are integrated with our GMP capabilities to enable a seamless transition from early research to clinical manufacturing.
Gaurav Sahay
Portland, USA
Talk title:
Chasing the Elusive Escape: Measuring Endosomal Trafficking In Vivo to Build Better Lipid Nanoparticles
Content of the talk
Endosomal escape is the central bottleneck in LNP-based RNA delivery, yet it has never been directly measurable in vivo so we developed a Lysosomal Barcoding assay in LysoTag mice that revealed only ~8% of our lead lipid’s particles reach the cytosol within 30 minutes, alongside a new class of branched ionizable phospholipids (BiP-20) that outperforms the clinical benchmark by eightfold for CRISPR editing in the liver. By pairing this quantitative escape readout with lysosomal proteomics, we uncovered the endolysosomal trafficking machinery that governs escape turning endosomal escape from a black box into a measurable, engineerable design parameter for the next generation of RNA medicines.
Rok Sekirnik
Ajdovščina, Slovenia
Talk title:
Increasing mRNA Yield Without Increasing Complexity
Content of the talk
Better process understanding drives better mRNA manufacturing. Discover how integrating advanced analytics, data-driven IVT optimization, and scalable purification technologies can increase functional mRNA yield, reduce impurities, and accelerate process development from concept to clinic.
Xiangrong Song
Chengdu, China
Talk title:
Advancing LNP Systems for Clinical Development of mRNA-based Medicines
Content of the talk
Christopher Stach
Boston, USA
Talk title:
Codon optimization and AI-guided 5′UTR generation for enhanced mRNA expression
Content of the talk
Ying Tam
Vancouver, Canada
Talk title:
Advancing LNP Systems for Clinical Development of mRNA-based Medicines
Luke Timoldi
Burlington, USA
Hamid Trimech
Tokyo, Japan
Talk title:
Establishing DS/DP End-to-End Manufacturing Capability of mRNA Vaccines and Therapeutics
Content of the talk
ARCALIS successfully achieved commercial manufacturing and shipment of KOSTAIVE®, Japan’s first self-amplifying mRNA vaccine.
This presentation will highlight the journey to commercialization and introduce ARCALIS’s current and future end-to-end DS/DP manufacturing capabilities for mRNA vaccines and therapeutics.
Srivats Venkataramanan
Emeryville, USA
Talk title:
First principles design of PRINT™, a new class of RNA medicines for durable genomic integration
Content of the talk
PRINT (Precise RNA-mediated Integration of Transgenes) is an all-RNA platform that co-delivers R2 retrotransposase mRNA and a template RNA by lipid nanoparticle to achieve durable transgene integration at the rDNA locus. Because the template RNA is never translated, the design rules the mRNA field has built around maximizing translation and managing immunogenicity do not transfer to it. This talk will discuss how a reexamination and rederivation of those rules from first principles led to a multi-log improvement in PRINT productivity.
Naoki Yamada
Cambridge, USA
Talk title:
Beyond the Liver: Well-Tolerated Novel Lipid and Ready to Use LNP Expanding mRNA Therapeutic Applications
Content of the talk
- High-safety-margin LNPs based on proprietary ionizable lipid technology
- Head-to-head comparison of FL-1245T and SM-86 in non-human primate intravenous studies
- Extrahepatic delivery enabled by formulation optimization of FL-1245T: A promising licensable ionizable lipid platform with an enhanced safety profile
- Ex vivo LNP delivery systems enabling high transfection efficiency and cell viability as an application of mRNA-LNP technologies in next-generation cell therapies
Tomoyoshi Yamano
Kanazawa, Ishikawa, Japan
Talk title:
A modular mRNA platform for in vivo induction of antigen-specific immune tolerance
Content of the talk
This talk will introduce a modular mRNA platform designed to induce antigen-specific immune tolerance in vivo by co-delivering antigen and regulatory signals. I will discuss the design principles of the platform, its ability to induce antigen-specific regulatory immune responses, and its therapeutic potential in autoimmune and allergic disease models.
Ed Yaworski
Basel, Switzerland
Talk title:
Innovative biodegradable lipids enable potent and safe delivery of nucleic acid therapeutics
Content of the talk
Hepatic and Extrahepatic Nucleic Acid Delivery via LNP.